Faculty Biography

Pandu Gangula, PhD

Professor
Oral Diagnostic Sciences & Research
School of Dentistry
(615) 327-6511 | Pgangula@mmc.edu

Center Affiliations

Center for Women’s Health Research, Center for Advanced Scientific Computing and Innovation, Health Disparities Research Center of Excellence, Center for Molecular & Behavioral Neuroscience

Research Themes

Cardiovascular Disease, Diabetes, Gastrointestinal Diseases, Infectious Diseases, Neurodegenerative Diseases, NeuroImmunotherapy, Obesity

Active Research Projects

1. Role of Nrf2 in Nitrergic mediated stomach motility in idiopathic, obesity and diabetic rodent models: SC1 (NIGMS)

2. Role of sex hormones and gastrointestinal and cardiovascular function in idiopathic, obesity and diabetic rodent models (SC1, (NIGMS))

3. Role of periodontal pathogens in gastrointestinal function in idiopathic, obesity and diabetic rodent models (submitted R01)

4. Racial disparity in colitis: Implications to colon motility- MeTRC

5. Changes in oral & gut microbiome and inflammatory cytokines in HIV patients: Effect of dental treatment (CFAR)

6.Role of periodontal pathogens in cardiovascular function in idiopathic, obesity and diabetic rodent models (developing to submit a grant)

Goals Schematic

Research - flow chart

Publications

COVID-19 and Cancer Comorbidity: Therapeutic Opportunities and Challenges.
Anup S Pathania, Philip Prathipati, Bakrudeen Aa Abdul, Srinivas Chava, Santharam S Katta, Subash C Gupta, Pandu R Gangula, Manoj K Pandey, Donald L Durden, Siddappa N Byrareddy, Kishore B Challagundla

Porphyromonas gingivalis infection alters Nrf2-Phase II enzymes and nitric oxide in primary human aortic endothelial cells.
Chethan Sampath, Emmanuel U Okoro, Michael J Gipson, Sasanka S Chukkapalli, Cherae M Farmer-Dixon, Pandu R Gangula

Inhibition of GSK-3β restores delayed gastric emptying in obesity-induced diabetic female mice.
Chethan Sampath, Shanthi Srinivasan, Michael L Freeman, Pandu R Gangula

Activation of Nrf2 attenuates delayed gastric emptying in obesity induced diabetic (T2DM) female mice.
Chethan Sampath, Jeremy C Sprouse, Michael L Freeman, Pandu R Gangula


Keywords

Sex hormones, Nitric Oxide, Nitric oxide synthases, Nrf2, Oxidative stress, Antioxidants, Inflammatory cytokines, molecular and cellular mechanisms

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